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Binimetinib (Standard)

CAT: 0804-HY-15202R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15202R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Binimetinib (Standard) is the analytical standard of Binimetinib. This product is intended for research and analytical applications. Binimetinib (MEK162) is an oral and selective MEK1/2 inhibitor. Binimetinib (MEK162) inhibits MEK with an IC50 of 12 nM.
CAS Number
606143-89-9
Product Name Alternative
MEK162 (Standard) ; ARRY-162 (Standard) ; ARRY-438162 (Standard)
UNSPSC
12352005
Hazard Statement
H411
Target
Autophagy; MEK; Reference Standards
Type
Reference Standards
Related Pathways
Autophagy; MAPK/ERK Pathway; Others
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/binimetinib-standard.html
Smiles
BrC1=CC=C(C(F)=C1)NC2=C(C3=C(C=C2C(NOCCO)=O)N(C=N3)C)F
Molecular Formula
C17H15BrF2N4O3
Molecular Weight
441.23
Precautions
P273-P391-P501
References & Citations
[1]J Pheneger, et al. 2006, ACR Annual Scientific Meeting. Abst 794.|[2]Serra V, et al. RSK3/4 mediate resistance to PI3K pathway inhibitors in breast cancer. J Clin Invest, 2013, 123 (6), 2551-2563.|[3]Kiessling MK, et al. Mutant HRAS as novel target for MEK and mTOR inhibitors. Oncotarget. 2015 Dec 8;6 (39) :42183-96.|[4]Cheng H, et al. PIK3CA (H1047R) - and Her2-initiated mammary tumors escape PI3K dependency by compensatory activation of MEK-ERK signaling. Oncogene. 2016 Jun 9;35 (23) :2961-70.|[5]Seip K, et al. Fibroblast-induced switching to the mesenchymal-like phenotype and PI3K/mTOR signaling protects melanoma cells from BRAF inhibitors. Oncotarget. 2016 Apr 12;7 (15) :19997-20015.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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