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TP0427736

CAT: 0931-T24897-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T24897-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
864374-00-5
Target
TGF-beta/Smad
Related Pathways
Stem Cells
Purity
0.9767
Bioactivity
TP0427736 is a potent and selective inhibitor of ALK5 with an IC50 of 2.72 nM, 300-fold higher than the inhibitory effect on ALK3. TP0427736 reduces TGF-β-induced growth inhibition in human outer root sheath cells and elongates the anagen phase in mouse hair follicles.
Smiles
CC=1N=C(C2=C(NC=N2)C=3C=C4C(=CC3)N=CS4)SC1
Molecular Formula
C14H10N4S2
Molecular Weight
298.39
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

6-(4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-5-yl)-1,3-benzothiazole

an ALK5 inhibitor; structure in first source

CAS Number864374-00-5
PubChem CID136105618
IUPAC Name6-[5-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-4-yl]-1,3-benzothiazole
Molecular FormulaC14H10N4S2
Molecular Weight298.4
XLogP3.3
Topological Polar Surface Area111
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Heavy Atom Count20
Formal Charge0
Complexity356
SMILES
CC1=CSC(=N1)C2=C(N=CN2)C3=CC4=C(C=C3)N=CS4
InChI
InChI=1S/C14H10N4S2/c1-8-5-19-14(18-8)13-12(15-6-16-13)9-2-3-10-11(4-9)20-7-17-10/h2-7H,1H3,(H,15,16)
InChIKey
LLFCXRYULHMNCG-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 6-(4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-5-yl)-1,3-benzothiazole
CAS: 864374-00-5
CID: 136105618
Formula: C14H10N4S2
MW: 298.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight298.4
XLogP33.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass298.03468868
Monoisotopic Mass298.03468868
Topological Polar Surface Area111 Ų
Heavy Atom Count20
Formal Charge0
Complexity356
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-118528TP0427736
MBS3846903-01TP0427736 HCl
GTR19187537-01TP0427736 hydrochloride
HY-118528A-01TP0427736 (hydrochloride)
A22382-50TP0427736 HCl 50mg
A22382-10TP0427736 HCl 10mg
A22382-100TP0427736 HCl 100mg
A22382-25TP0427736 HCl 25mg
A22382-5TP0427736 HCl 5mg
A22382-2TP0427736 HCl 2mg

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