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TP0427736 HCl

CAT: 1568-C13602-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:1568-C13602-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
864374-00-5
SKU
C13602-5mg
Target
TGF-beta/Smad
Applications
TGF-beta/Smad
Smiles
CC1=CSC (=N1) C2=C (N=CN2) C3=CC4=C (C=C3) N=CS4
Molecular Formula
C14H11ClN4S2
Additionnal Information
TP0427736 is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50 = 836 nM for ALK3) . It also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM.
Storage Conditions
3 years -20°C powder

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