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TP0427736 (hydrochloride)

CAT: 0804-HY-118528A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-118528A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TP0427736 hydrochloride is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50=836 nM) . TP0427736 hydrochloride also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM. TP0427736 hydrochloride can be used for the research of androgenic alopecia (AGA) [1].
CAS Number
2459963-17-6
Product Name Alternative
BAW2881
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
TGF-β Receptor
Type
Reference compound
Related Pathways
TGF-beta/Smad
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/tp0427736-hydrochloride.html
Purity
99.22
Solubility
DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 3.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC1=CSC(C2=C(C3=CC=C4N=CSC4=C3)N=CN2)=N1.[H]Cl
Molecular Formula
C14H11ClN4S2
Molecular Weight
334.85
Precautions
H302, H315, H319, H335
References & Citations
[1]Takumi Naruse, et al. Novel ALK5 inhibitor TP0427736 reduces TGF-β induced growth inhibition in human outer root sheath cells and elongates anagen phase in mouse hair follicles. Pharmacol Rep. 2017 May;69 (3) :485-491.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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