Products for Research Use Only
RegisterLogin

TCO-NHS ester

CAT: 0804-HY-141165-01Size: 50 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-141165-01Size:50 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
TCO-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. TCO-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
CAS Number
1191901-33-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tco-nhs-ester.html
Purity
97.0
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 52°C)
Smiles
O=C(OC1CC/C=C/CCC1)ON2C(CCC2=O)=O
Molecular Formula
C13H17NO5
Molecular Weight
267.28
Precautions
H302, H315, H319, H335
References & Citations
[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Alkyl/ether Linkers

Related Products

CatalogName
HY-141170-01TCO-PEG12-NHS ester
HY-141166TCO-PEG3-NHS ester
HY-171559TCO-PEG5-NHS ester
HY-141171TCO-PEG24-NHS ester
HY-141168TCO-PEG6-NHS ester
HY-202399TCO-PEG2-NHS ester
HY-141167TCO-PEG4-NHS ester
HY-141169-01TCO-PEG8-NHS ester
HY-141167A-01TCO-PEG4-NHS ester
HY-141167B(S) -TCO-PEG4-NHS ester

Alternative Products

CatalogName
sc-498419TCO-NHS ester
T207010-01TCO-PEG2-NHS ester
T18756-01TCO-PEG12-NHS ester
T18761-01TCO-PEG24-NHS ester
T18768-01TCO-PEG3-NHS ester
MBS5771641TCO-PEG8-NHS ester
BUP06120-01TCO-PEG4-NHS ester
GTR19258093-01TCO-PEG5-NHS ester
MBS5771638TCO-PEG6-NHS ester
T89807-01TCO-NHS Ester (axial)

Popular Products