TCO-PEG12-NHS ester

• UNSPSC Description:

  TCO-PEG12-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. TCO-PEG12-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. TCO-PEG12-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

• Target Antigen:

  ADC Linker; PROTAC Linkers

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/tco-peg12-nhs-ester.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(OC1CC/C=C\CCC1)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON2C(CCC2=O)=O)=O

• Molecular Weight:

  866.99

• References & Citations:

  [1]Leon S. FARHI, et al. Compositions and methods for high-sensitivity immunoassays. WO2018027221A1

• Shipping Conditions:

  Blue Ice

• Clinical Information:

  No Development Reported

• CAS Number:

  2185016-39-9