CL2 Linker

• Target :

  ADC Linker

• Related Pathways :

  Antibody-drug Conjugate/ADC Related

• Bioactivity :

  CL2 Linker is a cleavableADC linker. CL2-SN-38 and CL2A-SN-38 are equivalent in drug substitution (~6), cell binding (Kd ~1.2 nM), cytotoxicity (IC50 ~2.2 nM), and serum stability in vitro (t1/2 ~20 hours) [1][2].

• Smiles :

  [C@H](CC1=CC=CC=C1)(C(N[C@H](C(NC2=CC=C(COC(N(CCN(C(OCC(CO)=O)=O)C)C)=O)C=C2)=O)CCCCNC(OC(C)(C)C)=O)=O)NC(CCOCCOCCOCCOCCOCCOCCOCCOCCN3C=C(CNC(CCCCCN4C(=O)C=CC4=O)=O)N=N3)=O

• Molecular Formula :

  C68H103N11O22

• Molecular Weight :

  1426.61

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2270986-66-6