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PF-06263276

CAT: 0931-T16488-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T16488-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1421502-62-6
Target
Others, STAT, JAK
Related Pathways
Chromatin/Epigenetic, Tyrosine Kinase/Adaptors, JAK/STAT signaling, Angiogenesis, Others, Stem Cells
Bioactivity
PF-06263276 is an effective and selective inhibitor of pan-JAK. It also has IC50s of 2.2 nM, 23.1 nM, 59.9 nM and 29.7 nM for JAK1, JAK2, JAK3, and TYK2, respectively.
Smiles
CCc1cc(O)c(F)cc1-c1ccc2c(n[nH]c2c1)-c1nc2CCN(Cc2[nH]1)C(=O)c1cnc(cn1)N1CCCCC1
Molecular Formula
C31H31FN8O2
Molecular Weight
566.63
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

PF-06263276

a pan-Janus kinase inhibitor; structure in first source

CAS Number1421502-62-6
PubChem CID135567296
IUPAC Name[2-[6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl]-3,4,6,7-tetrahydroimidazo[4,5-c]pyridin-5-yl]-(5-piperidin-1-ylpyrazin-2-yl)methanone
Molecular FormulaC31H31FN8O2
Molecular Weight566.6
XLogP4.1
Topological Polar Surface Area127
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Heavy Atom Count42
Formal Charge0
Complexity941
SMILES
CCC1=CC(=C(C=C1C2=CC3=C(C=C2)C(=NN3)C4=NC5=C(N4)CN(CC5)C(=O)C6=CN=C(C=N6)N7CCCCC7)F)O
InChI
InChI=1S/C31H31FN8O2/c1-2-18-13-27(41)22(32)14-21(18)19-6-7-20-24(12-19)37-38-29(20)30-35-23-8-11-40(17-26(23)36-30)31(42)25-15-34-28(16-33-25)39-9-4-3-5-10-39/h6-7,12-16,41H,2-5,8-11,17H2,1H3,(H,35,36)(H,37,38)
InChIKey
XDJGNPSZQSWJCV-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of PF-06263276
CAS: 1421502-62-6
CID: 135567296
Formula: C31H31FN8O2
MW: 566.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight566.6
XLogP34.1
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Exact Mass566.25540042
Monoisotopic Mass566.25540042
Topological Polar Surface Area127 Ų
Heavy Atom Count42
Formal Charge0
Complexity941
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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MBS3601766-01PF-06263276
A12572-50PF-06263276 50mg
A12572-5PF-06263276 5mg
A12572-100PF-06263276 100mg
A12572-2PF-06263276 2mg
HY-101024RPF-06263276 (Standard)
A12572-25PF-06263276 25mg
A12572-10PF-06263276 10mg
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