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PF-05139962

CAT: 0931-T70782-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T70782-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1393712-18-9
Target
Others
Related Pathways
Others
Bioactivity
PF-05139962 is a novel potent mTOR inhibitor with excellent mTOR biochemical inhibition, cellular potency, kinase selectivity and in vitro ADME properties. PF-05139962 has pS473 and pS6 cellular IC50 = 48 and 6 nM respectively. PF-05139962 has great selectivity against other receptors and kinases. No genotoxicity was observed on this compound and no more than 25% inhibiton was observed for major CYP enzymes (3A4, 1A2, 2C9, 2D6) at 3 uM. This compound has LE = 0.35 and LipE up to 6.8 which is in a very desirable range for a kinase inhibitor.
Smiles
C[C@@H]1N(C2=C3C(=NC(=N2)C4=CC=C(NC(NCC)=O)C=C4)CCS(=O)(=O)C3)CCOC1
Molecular Formula
C21H27N5O4S
Molecular Weight
445.54
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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