PF-05139962

• Target:

  Others

• Related Pathways:

  Others

• Bioactivity:

  PF-05139962 is a novel potent mTOR inhibitor with excellent mTOR biochemical inhibition, cellular potency, kinase selectivity and in vitro ADME properties. PF-05139962 has pS473 and pS6 cellular IC50 = 48 and 6 nM respectively. PF-05139962 has great selectivity against other receptors and kinases. No genotoxicity was observed on this compound and no more than 25% inhibiton was observed for major CYP enzymes (3A4, 1A2, 2C9, 2D6) at 3 uM. This compound has LE = 0.35 and LipE up to 6.8 which is in a very desirable range for a kinase inhibitor.

• Smiles:

  C[C@@H]1N (C2=C3C (=NC (=N2) C4=CC=C (NC (NCC) =O) C=C4) CCS (=O) (=O) C3) CCOC1

• Molecular Formula:

  C21H27N5O4S

• Molecular Weight:

  445.54

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1393712-18-9