PF-303

CAT: 0931-T70393-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T70393-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1609465-78-2

Target

BTK, Others

Related Pathways

Angiogenesis, Others, Tyrosine Kinase/Adaptors

Bioactivity

PF-303 is a covalent-reversible BTK inhibitor. Inhibitors of Bruton's tyrosine kinase (BTK) possess much promise for the treatment of oncologic and autoimmune indications.

Smiles

C(N)(=O)C=1C(=NN(C1N)[C@H]2CN(C#N)CCC2)C3=CC=C(OC4=CC=C(Cl)C=C4)C=C3

Molecular Formula

C22H21ClN6O2

Molecular Weight

436.89

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

5-amino-3-[4-(4-chlorophenoxy)phenyl]-1-[(3R)-1-cyanopiperidin-3-yl]pyrazole-4-carboxamide

CAS Number	1609465-78-2
PubChem CID	74222426
IUPAC Name	5-amino-3-[4-(4-chlorophenoxy)phenyl]-1-[(3R)-1-cyanopiperidin-3-yl]pyrazole-4-carboxamide
Molecular Formula	C22H21ClN6O2
Molecular Weight	436.9
XLogP	3.9
Topological Polar Surface Area	123
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	5
Heavy Atom Count	31
Formal Charge	0
Complexity	670

SMILES

C1C[C@H](CN(C1)C#N)N2C(=C(C(=N2)C3=CC=C(C=C3)OC4=CC=C(C=C4)Cl)C(=O)N)N

InChI

InChI=1S/C22H21ClN6O2/c23-15-5-9-18(10-6-15)31-17-7-3-14(4-8-17)20-19(22(26)30)21(25)29(27-20)16-2-1-11-28(12-16)13-24/h3-10,16H,1-2,11-12,25H2,(H2,26,30)/t16-/m1/s1

InChIKey

YQUQOLJFVODMTO-MRXNPFEDSA-N

Chemical Structure

2D Structure

CAS: 1609465-78-2

CID: 74222426

Formula: C22H21ClN6O2

MW: 436.9

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	436.9
XLogP3	3.9
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	5
Exact Mass	436.1414516
Monoisotopic Mass	436.1414516
Topological Polar Surface Area	123 Å²
Heavy Atom Count	31
Formal Charge	0
Complexity	670
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
T7653-01	JNJ 303
T9901A-054-01	ABBV-303
T9901A-1038-01	FM-303
T70615-01	TAS-303
T11087-01	DOV-216,303 Free Base
T9901A-1753-01	PF-04840082
T28360-01	PF-00489791
T16493-01	PF-06465469
T36017-01	PF-05381941
T39248-01	PF-06426779

Alternative Products

Catalog	Name
HY-164002	PF-303
452867-01	JNJ 303
HY-P991276	FM-303
MBS5813154	TAS-303
iha-012	Wyoming 303
HY-179219S	RTx-303
P1731	PEarleyGate 303

PF-303

Chemical Information

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