GNE-5729

• Target:

  IGluR|||NMDAR

• Related Pathways:

  Membrane transporter/Ion channel|||Neuroscience

• Purity:

  0.9985

• Bioactivity:

  GNE-5729 is a positive allosteric modulator of NMDAR with the advantage of crossing the blood-brain barrier and being orally available, with EC50 values of 37 nM, 4.7 ?M and 9.5 ?M for GluN2A, GluN2C and GluN2D, respectively, and can be used for the study of neurological and psychiatric disorders.

• Smiles:

  ClC1=C (N2C (=NC (CN3N=C (C (F) (F) F) C=C3Cl) =CC2=O) C=C1) [C@H]4[C@H] (C#N) C4

• Molecular Formula:

  C17H10Cl2F3N5O

• Molecular Weight:

  428.2

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2026635-66-3