GNE-0946

• Target:

  ROR

• Related Pathways:

  Metabolism

• Bioactivity:

  GNE-0946 is an effective and selective ROR?/RORc/NR1F3 antagonist (inverse agonist) with an EC50 of 4 nM in HEK-293 cells. It inhibits IL-17 production in human PBMC cells (IC50 = 17 nM) and can be used in autoimmune disease research.

• Smiles:

  O=C(O)C=1C=CC(=CC1O)C=2N=C(C(=O)C=3C(Cl)=CC=CC3C(F)(F)F)N4C=CC=CC24

• Molecular Formula:

  C22H12ClF3N2O4

• Molecular Weight:

  460.79

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1677667-24-1