CU-T12-9

• Target :

  TLR

• Related Pathways :

  Immunology/Inflammation

• Purity :

  0.9993

• Bioactivity :

  CU-T12-9 is a potent TLR1/2 agonist (EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay) . It acts by activating the NFkB pathway, upregulating proinflammatory cytokines, and enhancing TLR1 and TLR2 dimerization.CU-T12-9 activates both the innate and the adaptive immune systems. CU-T12-9 selectively activates the TLR1/2 heterodimer, not TLR2/6. CU-T12-9 signals through NF-?B and invokes an elevation of the downstream effectors TNF-?, IL-10, and iNOS.

• Smiles :

  CNc1ccc(cc1-n1cnc(c1)-c1ccc(cc1)C(F)(F)F)[N+]([O-])=O

• Molecular Formula :

  C17H13F3N4O2

• Molecular Weight :

  362.31

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1821387-73-8