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CU-T12-9

CAT: 0931-T15017-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T15017-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1821387-73-8
Target
TLR
Related Pathways
Immunology/Inflammation
Purity
0.9993
Bioactivity
CU-T12-9 is a potent TLR1/2 agonist (EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay) . It acts by activating the NFkB pathway, upregulating proinflammatory cytokines, and enhancing TLR1 and TLR2 dimerization.CU-T12-9 activates both the innate and the adaptive immune systems. CU-T12-9 selectively activates the TLR1/2 heterodimer, not TLR2/6. CU-T12-9 signals through NF-κB and invokes an elevation of the downstream effectors TNF-α, IL-10, and iNOS.
Smiles
CNc1ccc(cc1-n1cnc(c1)-c1ccc(cc1)C(F)(F)F)[N+]([O-])=O
Molecular Formula
C17H13F3N4O2
Molecular Weight
362.31
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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445157-01CU-T12-9
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