AMG-1694

• Target:

  Glucokinase

• Related Pathways:

  Metabolism

• Purity:

  0.9837

• Bioactivity:

  AMG-1694, a potent disruptor of the glucokinase–glucokinase regulatory protein (GK-GKRP) complex, operates by promoting the dissociation of this complex, thereby indirectly enhancing GK enzymatic activity with an IC50 of 7 nM. It effectively normalizes blood glucose levels in various rodent diabetes models [1] and lowers blood glucose specifically in diabetic animals without affecting normoglycemic ones. Additionally, AMG-1694 reverses the GKRP-induced inhibition of GK activity and facilitates GK translocation.

• Smiles:

  C ([C@@H]1N (CCN (S (=O) (=O) C2=CC=CS2) C1) C3=CC=C ([C@@] (C (F) (F) F) (C) O) C=C3) N4[C@@H] (C) COCC4

• Molecular Formula:

  C23H30F3N3O4S2

• Molecular Weight:

  533.63

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1361217-07-3