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AMG-1694

CAT: 0931-T14212-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T14212-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1361217-07-3
Target
Glucokinase
Related Pathways
Metabolism
Purity
0.9837
Bioactivity
AMG-1694, a potent disruptor of the glucokinase–glucokinase regulatory protein (GK-GKRP) complex, operates by promoting the dissociation of this complex, thereby indirectly enhancing GK enzymatic activity with an IC50 of 7 nM. It effectively normalizes blood glucose levels in various rodent diabetes models [1] and lowers blood glucose specifically in diabetic animals without affecting normoglycemic ones. Additionally, AMG-1694 reverses the GKRP-induced inhibition of GK activity and facilitates GK translocation.
Smiles
C([C@@H]1N(CCN(S(=O)(=O)C2=CC=CS2)C1)C3=CC=C([C@@](C(F)(F)F)(C)O)C=C3)N4[C@@H](C)COCC4
Molecular Formula
C23H30F3N3O4S2
Molecular Weight
533.63
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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