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AZD-8529 (mesylate)

CAT: 0804-HY-107457A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107457A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AZD-8529 mesylate is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes[1].
CAS Number
1314217-69-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/azd-8529-mesylate.html
Purity
99.59
Solubility
DMSO : 41.67 mg/mL (ultrasonic)
Smiles
O=C1C2=C(C)C=C(C3=NC(CN4CCNCC4)=NO3)C=C2CN1CC5=CC=C(OC(F)(F)F)C=C5.OS(=O)(C)=O
Molecular Formula
C25H28F3N5O6S
Molecular Weight
583.58
Precautions
H302, H315, H319, H335
References & Citations
[1]Justinova Z, et al. The Novel Metabotropic Glutamate Receptor 2 Positive Allosteric Modulator, AZD8529, Decreases Nicotine Self-Administration and Relapse in Squirrel Monkeys. Biol Psychiatry. 2015 Oct 1;78 (7) :452-62.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
MGluR2

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