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EGFR mutant-IN-1

CAT: 0013-GTR19229763-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19229763-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EGFR mutant-in-1 is a potent and selective 5-methylpyrimidopyridone inhibitor targeting the EGFRL858R/T790M/C797S triple mutant with an IC50 of 27.5 nM, while exhibiting minimal activity against wild-type EGFR. This compound serves as a valuable chemical probe for studying resistance mechanisms in non-small cell lung cancer, applicable in both in vitro biochemical and cellular assays.
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Smiles
O=C1C (C2=CC=CC (F) =C2Cl) =C (C) C3=CN=C (NC4=CC=C (N5CCN (C) CC5) C (C) =C4) N=C3N1[C@H]6CN (C (CC) =O) CCC6
Molecular Formula
C34H39ClFN7O2
Molecular Weight
632.17
Storage Conditions
-20°C
Notes
For research use only.

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