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Mutated EGFR-IN-2

CAT: 0804-HY-128860Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-128860Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mutated EGFR-IN-2 (compound 91) is a mutant-selective EGFR inhibitor extracted from patent WO2017036263A1, which potently inhibits single-mutant EGFR (T790M) and double-mutant EGFR (including L858R/T790M (IC50=[1].
CAS Number
2050906-97-1
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mutated-egfr-in-2.html
Solubility
10 mM in DMSO
Smiles
C=CC(NC1=CC(NC2=NC=CC(N3C4=CC=C(F)C=C4N(C(C)C)C3=O)=N2)=C(OC)C=C1N(CCN(C)C)C)=O
Molecular Formula
C29H35FN8O3
Molecular Weight
562.64
References & Citations
[1]2, 4-di- (nitrogen containing group) substituted pyrimidine compound and preparation method and use thereof.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1

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