CSRM617

• Target :

  Apoptosis|||Androgen Receptor|||Others

• Related Pathways :

  Endocrinology/Hormones|||Apoptosis|||Others

• Bioactivity :

  CSRM617 is a selective small molecule inhibitor of the transcription factor ONECUT2 (OC2, the main regulator of androgen receptor) . The Kd in SPR analysis is 7.43 uM, which can directly bind to the OC2-HOX domain. CSRM617 induces apoptosis by cleaving the presence of Caspase-3 and PARP. CSRM617 is well tolerated in a mouse model of prostate cancer.

• Smiles :

  C(=NNC(C(CO)N)=O)C1=C(O)C(O)=C(O)C=C1

• Molecular Formula :

  C10H13N3O5

• Molecular Weight :

  255.23

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  787504-88-5