CSRM617 hydrochloride

• Description:

  CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor), with a Kd of 7.43 µM in SPR assays, directly binding to the OC2-HOX domain. CSRM617 hydrochloride induces apoptosis through the appearance of cleaved Caspase-3 and PARP and is well tolerated in the mouse model of prostate cancer .

• Stability:

  ≥ 2 years

• Purity:

  >98% (HPLC)

• Weight:

  291.69

• Molecular Formula:

  C10H14ClN3O5

• Notes:

  Research use only, not for human use.

• Receptor:

  Apoptosis | Androgen Receptor

• CAS Number:

  1353749-74-2