CSRM617 (Standard)

• Description :

  CSRM617 (Standard) is the analytical standard of CSRM617. This product is intended for research and analytical applications. CSRM617 is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a Kd of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 induces apoptosis by appearance of cleaved Caspase-3 and PARP. CSRM617 is well tolerated in the prostate cancer mouse model[1]

• UNSPSC :

  12352005

• Target :

  Androgen Receptor; Apoptosis; Reference Standards

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Others; Vitamin D Related/Nuclear Receptor

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/csrm617-standard.html

• Smiles :

  O=C(C(CO)N)N/N=C/C1=CC=C(C(O)=C1O)O

• Molecular Formula :

  C10H13N3O5

• Molecular Weight :

  255.23

• References & Citations :

  [1]Rotinen M, et al. ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis. Nat Med. 2018 Dec;24 (12) :1887-1898.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference Standards

• CAS Number :

  [787504-88-5]