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CSRM617 (hydrochloride)

CAT: 0804-HY-122611A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-122611A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a Kd of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 hydrochloride induces apoptosis by appearance of cleaved Caspase-3 and PARP. CSRM617 hydrochloride is well tolerated in the prostate cancer mouse model[1]
CAS Number
1353749-74-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Androgen Receptor; Apoptosis
Type
Reference compound
Related Pathways
Apoptosis; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/csrm617-hydrochloride.html
Purity
99.97
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C(CO)N)N/N=C/C1=CC=C(C(O)=C1O)O.[H]Cl
Molecular Formula
C10H14ClN3O5
Molecular Weight
291.69
Precautions
H302, H315, H319, H335
References & Citations
[1]Rotinen M, et, al. ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis. Nat Med. 2018 Dec;24 (12) :1887-1898.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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