CSRM617

• Description:

  CSRM617 is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a Kd of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 induces apoptosis by appearance of cleaved Caspase-3 and PARP. CSRM617 is well tolerated in the prostate cancer mouse model[1]

• UNSPSC:

  12352005

• Target:

  Androgen Receptor; Apoptosis

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Vitamin D Related/Nuclear Receptor

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/csrm617.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C(CO)N)N/N=C/C1=CC=C(C(O)=C1O)O

• Molecular Formula:

  C10H13N3O5

• Molecular Weight:

  255.23

• References & Citations:

  [1]Rotinen M, et al. ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis. Nat Med. 2018 Dec;24 (12) :1887-1898.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [787504-88-5]