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CCR2 antagonist 5

CAT: 0931-T27682-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T27682-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1228650-83-6
Target
CCR
Related Pathways
GPCR/G Protein, Microbiology/Virology, Immunology/Inflammation
Purity
0.9998
Bioactivity
CCR2 antagonist 5 (JNJ-41443532) is a selective and orally active hCCR2 inhibitor with good binding affinity (IC50=37 nM) and potent functional antagonism (chemotaxis IC50=30 nM) .JNJ-41443532 binds mCCR2 with a Ki of 9.6 μM, which can be used to study inflammatory diseases and diabetes. diseases and diabetes.
Smiles
N(C(CNC(=O)C1=CC(C(F)(F)F)=CC=C1)=O)C2CN([C@@H]3CC[C@@](O)(CC3)C4=CN=CS4)C2
Molecular Formula
C22H25F3N4O3S
Molecular Weight
482.52
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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