AMG 487

• Target :

  CXCR

• Related Pathways :

  GPCR/G Protein|||Autophagy|||Immunology/Inflammation

• Purity :

  0.9989

• Bioactivity :

  AMG 487 is a potent and selective antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively.

• Smiles :

  CCOc1ccc(cc1)-n1c(nc2ncccc2c1=O)[C@@H](C)N(Cc1cccnc1)C(=O)Cc1ccc(OC(F)(F)F)cc1

• Molecular Formula :

  C32H28F3N5O4

• Molecular Weight :

  603.59

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  473719-41-4