Oltipraz

CAT: 0931-T0153-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0931-T0153-01Size:5 mg

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CAS Number

64224-21-1

Target

Nrf2, Parasite, Reverse Transcriptase, HIF/HIF Prolyl-Hydroxylase, HIV Protease, HIF

Related Pathways

Proteases/Proteasome, Immunology/Inflammation, Chromatin/Epigenetic, Metabolism, Microbiology/Virology, Angiogenesis

Purity

>99.99%

Bioactivity

Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as glutathione S transferase (GST) and NAD (P) H: quinone oxidoreductase 1 (NQO1) . The induction of detoxification enzymes enhances the detoxification of certain cancer-causing agents, thereby enhancing their elimination and preventing carcinogen-induced DNA damages. Although the exact mechanism through which the anti-angiogenesis effect remains to be fully elucidated, oltipraz maybe able to modulate the expression of a number of angiogenic factors, thereby blocking the sustained and focal neovascularization in multiple tumor cell types.

Smiles

CC1=C(SSC1=S)C1=NC=CN=C1

Molecular Formula

C8H6N2S3

Molecular Weight

226.34

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

Oltipraz

Oltipraz is a 1,2-dithiole that is 3H-1,2-dithiole-3-thione substituted at positions 4 and 5 by methyl and pyrazin-2-yl groups respectively. It has a role as an antioxidant, an EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor, an antineoplastic agent, a schistosomicide drug, a protective agent, a neurotoxin, an angiogenesis modulating agent and an antimutagen. It is a member of pyrazines and a 1,2-dithiole.

CAS Number	64224-21-1
PubChem CID	47318
IUPAC Name	4-methyl-5-pyrazin-2-yldithiole-3-thione
Molecular Formula	C8H6N2S3
Molecular Weight	226.3
XLogP	1.1
Topological Polar Surface Area	108
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	1
Heavy Atom Count	13
Formal Charge	0
Complexity	262

SMILES

CC1=C(SSC1=S)C2=NC=CN=C2

InChI

InChI=1S/C8H6N2S3/c1-5-7(12-13-8(5)11)6-4-9-2-3-10-6/h2-4H,1H3

InChIKey

CKNAQFVBEHDJQV-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 64224-21-1

CID: 47318

Formula: C8H6N2S3

MW: 226.3

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	226.3
XLogP3	1.1
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	1
Exact Mass	225.96931172
Monoisotopic Mass	225.96931172
Topological Polar Surface Area	108 Å²
Heavy Atom Count	13
Formal Charge	0
Complexity	262
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
MBS577927	Oltipraz

Oltipraz

Chemical Information

Alternative Products

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