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Oltipraz-d3

CAT: 0804-HY-12519SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12519SSize:1 mg
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Description
Oltipraz-d3 is the deuterium labeled Oltipraz. Oltipraz has an inhibitory effect on HIF-1α activation in a time-dependent manner, completely abrogating HIF-1α induction at ≥10 μM concentrations, the IC50 of Oltipraz for HIF-1α inhibition is 10 μM. Oltipraz is a potent Nrf2 activator.
CAS Number
2012598-51-3
Product Name Alternative
RP 35972-d3; NSC 347901-d3
UNSPSC
12352005
Target
HIF/HIF Prolyl-Hydroxylase; HIV; Isotope-Labeled Compounds; Keap1-Nrf2
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Metabolic Enzyme/Protease; NF-κB; Others
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
S=C1SSC(C2=NC=CN=C2)=C1C([2H])([2H])[2H]
Molecular Formula
C8H3D3N2S3
Molecular Weight
229.36
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Lee WH, et al. Oltipraz and dithiolethione congeners inhibit hypoxia-inducible factor-1alpha activity through p70 ribosomal S6 kinase-1 inhibition and H2O2-scavenging effect. Mol Cancer Ther. 2009 Oct;8 (10) :2791-802.|[3]Ramos-Gomez M, et al. Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proc Natl Acad Sci U S A. 2001 Mar 13;98 (6) :3410-5.|[4]Lv S, et al. Glucagon-induced extracellular cAMP regulates hepatic lipid metabolism. J Endocrinol. 2017 Aug;234 (2) :73-87.|[5]Eba S, et al.The nuclear factor erythroid 2-related factor 2 activator oltipraz attenuates chronic hypoxia-induced cardiopulmonary alterations in mice.Am J Respir Cell Mol Biol. 2013 Aug;49 (2) :324-33.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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