Oltipraz

• Target :

  Nrf2|||Parasite|||Reverse Transcriptase|||HIF/HIF Prolyl-Hydroxylase|||HIV Protease|||HIF

• Related Pathways :

  Proteases/Proteasome|||Immunology/Inflammation|||Chromatin/Epigenetic|||Metabolism|||Microbiology/Virology|||Angiogenesis

• Purity :

  >99.99%

• Bioactivity :

  Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as glutathione S transferase (GST) and NAD (P) H: quinone oxidoreductase 1 (NQO1) . The induction of detoxification enzymes enhances the detoxification of certain cancer-causing agents, thereby enhancing their elimination and preventing carcinogen-induced DNA damages. Although the exact mechanism through which the anti-angiogenesis effect remains to be fully elucidated, oltipraz maybe able to modulate the expression of a number of angiogenic factors, thereby blocking the sustained and focal neovascularization in multiple tumor cell types.

• Smiles :

  CC1=C(SSC1=S)C1=NC=CN=C1

• Molecular Formula :

  C8H6N2S3

• Molecular Weight :

  226.34

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  64224-21-1