Gln-AMS (TFA)

CAT: 0804-HY-112861A-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-112861A-01Size:1 mg
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Description
Gln-AMS (TFA) is a type Ia aminoacyl-tRNA synthetase (AARS) inhibitor. Gln-AMS inhibits glutaminyl-tRNA synthetase (GlnRS) with a Ki of 1.32 μM.
UNSPSC
12352005
Target
Aminoacyl-tRNA Synthetase; Bacterial
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/Gln-AMS_TFA.html
Purity
99.85
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1=C2N=CN([C@@H]3O[C@H](COS(=O)(NC([C@@H](N)CCC(N)=O)=O)=O)[C@@H](O)[C@H]3O)C2=NC=N1.OC(C(F)(F)F)=O
Molecular Formula
C17H23F3N8O10S
Molecular Weight
588.47
References & Citations
[1]Rath VL, et al. How glutaminyl-tRNA synthetase selects glutamine. Structure. 1998 Apr 15;6 (4) :439-49.|[2]Fang P, et al. Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase. Nat Commun. 2015 Mar 31;6:6402.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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