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(rel) -ML-SI3

CAT: 0804-HY-139426A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-139426A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(rel) -ML-SI3 is one of the active ingredients of ML-SI3 (another component is (cis) -ML-SI3) that targets three isoforms of TRPML. (rel) -ML-SI3 is an inhibitor of TRPML1 and TRPML3 (IC50=3.1 μM/28.5 μM), and a potent activator of TRPML2 (EC50=3.3 μM)[2][3].
CAS Number
2108567-79-7
Product Name Alternative
Trans-ML-SI3
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; TRP Channel
Type
Reference compound
Related Pathways
Autophagy; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rel-ml-si3.html
Purity
98.94
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=S(N[C@H]1[C@H](N2CCN(C3=C(C=CC=C3)OC)CC2)CCCC1)(C4=CC=CC=C4)=O
Molecular Formula
C23H31N3O3S
Molecular Weight
429.58
Precautions
H302, H315, H319, H335
References & Citations
[1]Rühl P, et al. Estradiol analogs attenuate autophagy, cell migration and invasion by direct and selective inhibition of TRPML1, independent of estrogen receptors. Sci Rep. 2021 Apr 15;11 (1) :8313. [Content Brief]|[2]Xing Y, et al. Blunting TRPML1 channels protects myocardial ischemia/reperfusion injury by restoring impaired cardiomyocyte autophagy. Basic Res Cardiol. 2022 Apr 7;117 (1) :20. [Content Brief]|[3]Leser C, et al. Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3. Eur J Med Chem. 2021 Jan 15;210:112966.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TRPML1; TRPML2; TRPML3

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