(1R,2R)-ML-SI3
CAT:
804-HY-134819A-02
Size:
50 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
(1R,2R)-ML-SI3
- CAS Number: 2418594-00-8
- UNSPSC Description: (1R,2R)-ML-SI3 is an isomer of ML-SI3 and a potent inhibitor of three isoforms of TRPML. (1R,2R)-ML-SI3 inhibits TRPMLs with IC50s of 1.6 μM (TRPML1), 2.3 μM (TRPML2), and 12.5 μM (TRPML3), respectively[1].
- Target Antigen: TRP Channel
- Type: Reference compound
- Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling
- Field of Research: Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/1r-2r-ml-si3.html
- Smiles: COC1=CC=CC=C1N2CCN([C@@H]3CCCC[C@H]3NS(C4=CC=CC=C4)(=O)=O)CC2
- Molecular Weight: 429.58
- References & Citations: [1]Leser C, Keller M, Gerndt S, et al. Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3. Eur J Med Chem. 2021;210:112966.
- Shipping Conditions: Room Temperature