Notch 1

• Description :

  Notch 1 (Notch homolog 1, translocation-associated) can encode a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types[1].

• CAS Number :

  [2408730-51-6]

• UNSPSC :

  12352209

• Target :

  Notch

• Related Pathways :

  Neuronal Signaling; Stem Cell/Wnt

• Field of Research :

  Cancer; Cardiovascular Disease

• Purity :

  95.39

• Solubility :

  10 mM in DMSO

• Smiles :

  OC(CC[C@@H](C(O)=O)NC([C@H](CS)NC([C@H]([C@@H](C)CC)NC([C@H](CS)NC([C@H](CCC(N)=O)NC([C@@H](NC([C@H](CCC(O)=O)NC(CNC([C@H]([C@@H](C)CC)NC([C@H](CCC(N)=O)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@@H](N)CS)=O)=O)=O)=O)=O)=O)=O)CC1=CC=CC=C1)=O)=O)=O)=O)=O)=O

• Molecular Formula :

  C62H97N15O22S3

• Molecular Weight :

  1500.72

• References & Citations :

  [1]NOTCH1 notch receptor 1 [Homo sapiens (human) ] Gene ID: 4851, updated on 28-Oct-2019.|[2]toyanova T, et al. Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer. Proc Natl Acad Sci U S A. 2016 Oct 18;113 (42) :E6457-E6466.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported