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BVB-808

CAT: 0931-T71313-01Size: 25 mgDry Ice: NoHazardous: No
CAT#: T71313-01Size: 25 mg
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1180158-99-9
Target
Others
Related Pathways
Others
Bioactivity
BVB-808 is a selective Jak2 type 1 inhibitor. Janus kinases are critical components of signaling pathways that regulate hematopoiesis. Mutations of the non-receptor tyrosine kinase JAK2 are found in many BCR-ABL-negative myeloproliferative neoplasms. Preclinical results support that JAK2 inhibitors could show efficacy in treating chronic myeloproliferative neoplasms. JAK2 has also been postulated to play a role in BCR-ABL signal transduction. Therefore, inhibitors of JAK2 kinases are turning into therapeutic strategies for treatment of chronic myelogenous leukemia (CML) .
Smiles
N(C=1N=C2N(C=CC2=CN1)C3=CC(F)=C(CN4CCOCC4)C(F)=C3)C=5C=CC(=NC5)N6C[C@@H](C)N[C@@H](C)C6
Molecular Formula
C28H32F2N8O
Molecular Weight
534.6
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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