Indapamide

• Description:

  Indapamide is an orally active sulphonamide diuretic agent, that can reduce blood pressure by decreasing vascular reactivity and peripheral vascular resistance. Indapamide is also can reduce left ventricular hypertrophy[1][4].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Potassium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/Indapamide.html

• Purity:

  99.62

• Solubility:

  DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL

• Smiles:

  O=C (NN1C (C) CC2=C1C=CC=C2) C3=CC=C (Cl) C (S (=O) (N) =O) =C3

• Molecular Formula:

  C16H16ClN3O3S

• Molecular Weight:

  365.83

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Chaffman, M, et, al. Indapamide. Drugs 28, 189–235 (1984) .|[2]Furman BL, et, al. A further examination of the possible effects of indapamide on glucose tolerance and insulin secretion in the rat and mouse. J Pharm Pharmacol. 1981 Nov;33 (11) :735-7.|[3]Lalande A, et, al. Indapamide, a thiazide-like diuretic, decreases bone resorption in vitro. J Bone Miner Res. 2001 Feb;16 (2) :361-70.|[4]Ma F, et, al. Indapamide lowers blood pressure by increasing production of epoxyeicosatrienoic acids in the kidney. Mol Pharmacol. 2013 Aug;84 (2) :286-95.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• CAS Number:

  26807-65-8