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Indapamide (hemihydrate)

CAT: 0804-HY-B0259ASize: 1 EachDry Ice: NoHazardous: No
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Description
Indapamide hemihydrate is an orally active sulphonamide diuretic agent, that can reduce blood pressure by decreasing vascular reactivity and peripheral vascular resistance. Indapamide hemihydrate is also can reduce left ventricular hypertrophy[1][4].
CAS Number
180004-24-4
UNSPSC
12352005
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/indapamide-hemihydrate.html
Smiles
O=C(NN1C(C)CC2=C1C=CC=C2)C3=CC=C(Cl)C(S(=O)(N)=O)=C3.O.[0.5]
Molecular Formula
C16H16ClN3O3S.1/2H2O
Molecular Weight
749.69
References & Citations
[1]Chaffman, M, et, al. Indapamide. Drugs 28, 189–235 (1984) .|[2]Furman BL, et, al. A further examination of the possible effects of indapamide on glucose tolerance and insulin secretion in the rat and mouse. J Pharm Pharmacol. 1981 Nov;33 (11) :735-7.|[3]Lalande A, et, al. Indapamide, a thiazide-like diuretic, decreases bone resorption in vitro. J Bone Miner Res. 2001 Feb;16 (2) :361-70.|[4]Ma F, et, al. Indapamide lowers blood pressure by increasing production of epoxyeicosatrienoic acids in the kidney. Mol Pharmacol. 2013 Aug;84 (2) :286-95.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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