Indapamide-13C, d3

CAT: 0804-HY-B0259S1-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0259S1-01Size:1 mg
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Description
Indapamide-13C, d3 is 13C and deuterium labeled Indapamide. Indapamide is an orally active sulphonamide diuretic agent, that can reduce blood pressure by decreasing vascular reactivity and peripheral vascular resistance. Indapamide is also can reduce left ventricular hypertrophy[1][4][5].
CAS Number
[2934053-07-1]
UNSPSC
12352005
Target
Isotope-Labeled Compounds; Potassium Channel
Type
Isotope-Labeled Compounds
Related Pathways
Membrane Transporter/Ion Channel; Others
Field of Research
Cardiovascular Disease
Smiles
O=C(C1=CC=C(C(S(=O)(N)=O)=C1)Cl)NN2C3=C(CC2[13C]([2H])([2H])[2H])C=CC=C3
Molecular Formula
C15 13CH13D3ClN3O3S
Molecular Weight
369.85
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Chaffman, M, et, al. Indapamide. Drugs 28, 189–235 (1984) .|[3]Furman BL, et, al. A further examination of the possible effects of indapamide on glucose tolerance and insulin secretion in the rat and mouse. J Pharm Pharmacol. 1981 Nov;33 (11) :735-7.|[4]Lalande A, et, al. Indapamide, a thiazide-like diuretic, decreases bone resorption in vitro. J Bone Miner Res. 2001 Feb;16 (2) :361-70.|[5]Ma F, et, al. Indapamide lowers blood pressure by increasing production of epoxyeicosatrienoic acids in the kidney. Mol Pharmacol. 2013 Aug;84 (2) :286-95.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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