FKBP12, His-tag Recombinant

• Description:

  FKBP12, His-tag Recombinant_x000D_ Catalog number: B2019154_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 100 µg_x000D_ Molecular Weight or Concentration: 13.1 kDa_x000D_ Supplied as: Solution_x000D_ Applications: a molecular tool for various biochemical applications_x000D_ Storage: ˆ’80°C_x000D_ Keywords: FK506 Binding Protein 1, FKBP, Rotamase, Immunophilin FKBP12, PPIase, Calstabin_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Uchinomiya S, Nonaka H, Wakayama S, Ojida A, Hamachi I. In-cell covalent labeling of reactive His-tag fused proteins Chem Commun (Camb). 2013 Jun 4;49(44):5022-4._x000D_ 2: Imamura S, Ishiwata A, Watanabe S, Yoshikawa H, Tanaka K. Expression of budding yeast FKBP12 confers rapamycin susceptibility to the unicellular red alga Cyanidioschyzon merolae Biochem Biophys Res Commun. 2013 Sep 20;439(2):264-9._x000D_ 3: Meuvis J, Gerard M, Desender L, Baekelandt V, Engelborghs Y. The conformation and the aggregation kinetics of α-synuclein depend on the proline residues in its C-terminal region Biochemistry. 2010 Nov 2;49(43):9345-52._x000D_ 4: Girgenrath T, Mahalingam M, Svensson B, Nitu FR, Cornea RL, Fessenden JD. N-terminal and central segments of the type 1 ryanodine receptor mediate its interaction with FK506-binding proteins J Biol Chem. 2013 May 31;288(22):16073-84._x000D_ 5: Wear MA, Patterson A, Walkinshaw MD. A kinetically trapped intermediate of FK506 binding protein forms in vitro: chaperone machinery dominates protein folding in vivo Protein Expr Purif. 2007 Jan;51(1):80-95._x000D_ 6: Pettinato M, Dulja A, Colucci S, Furiosi V, Fette F, Steinbicker AU, Muckenthaler MU, Nai A, Pagani A, Silvestri L. FKBP12 inhibits hepcidin expression by modulating BMP receptors interaction and ligand responsiveness in hepatocytes Am J Hematol. 2023 Aug;98(8):1223-1235._x000D_ 7: Nabet B, Roberts JM, Buckley DL, Paulk J, Dastjerdi S, Yang A, Leggett AL, Erb MA, Lawlor MA, Souza A, Scott TG, Vittori S, Perry JA, Qi J, Winter GE, Wong KK, Gray NS, Bradner JE. The dTAG system for immediate and target-specific protein degradation Nat Chem Biol. 2018 May;14(5):431-441._x000D_ 8: Kasahara K. Physiological function of FKBP12, a primary target of rapamycin/FK506: a newly identified role in transcription of ribosomal protein genes in yeast Curr Genet. 2021 Jun;67(3):383-388._x000D_ 9: Quist-Løkken I, Andersson-Rusch C, Kastnes MH, Kolos JM, Jatzlau J, Hella H, Olsen OE, Sundan A, Knaus P, Hausch F, Holien T. FKBP12 is a major regulator of ALK2 activity in multiple myeloma cells Cell Commun Signal. 2023 Jan 30;21(1):25._x000D_ 10: Richardson SJ, Thekkedam CG, Casarotto MG, Beard NA, Dulhunty AF. FKBP12 binds to the cardiac ryanodine receptor with negative cooperativity: implications for heart muscle physiology in health and disease Philos Trans R Soc Lond B Biol Sci. 2023 Jun 19;378(1879):20220169. _x000D_ _x000D_ Products Related to FKBP12, His-tag Recombinant can be found at Proteins

• Short Description:

  Catalog Number: B2019154 (100 µg)_x000D_ FKBP12, or FK506-binding protein 12, is a protein in the immunophilin family. It plays a role in protein folding and cellular processes. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request._x000D_ _x000D_

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5

• CAS Number:

  9000-83-3