LX-1031

• Description:

  LX-1031 is a potent, orally available tryptophan 5-hydroxylase (TPH) inhibitor that reduces serotonin (5-HT) synthesis peripherally.

• UNSPSC:

  12352005

• Target:

  Tryptophan Hydroxylase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/LX-1031.html

• Purity:

  99.14

• Solubility:

  DMSO : ≥ 34 mg/mL

• Smiles:

  NC1=NC(C2=CC=C(C=C2)C[C@@H](C(O)=O)N)=CC(O[C@H](C3=CC=C(C4=CC(OC)=CC=C4)C=C3)C(F)(F)F)=N1

• Molecular Formula:

  C28H25F3N4O4

• Molecular Weight:

  538.52

• References & Citations:

  [1]Camilleri M. LX-1031, a tryptophan 5-hydroxylase inhibitor, and its potential in chronic diarrhea associated with increased serotonin. Neurogastroenterol Motil. 2011 Mar;23 (3) :193-200.|[2]Camilleri M. LX-1031, a tryptophan 5-hydroxylase inhibitor that reduces 5-HT levels for the potential treatment of irritable bowel syndrome. IDrugs. 2010 Dec;13 (12) :921-8.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• CAS Number:

  945976-76-1