LX-3

• UNSPSC Description:

  LX-3 is a selective activator of the p38 MAPK signaling pathway and activates EGFP reporter genes that are silenced by DNA methylation, such as TNF, EGR1, LY6K, and ISG20[1].

• Target Antigen:

  p38 MAPK

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/lx-3.html

• Smiles:

  BrC1=CC=C(C(CN2C3=NC(C4=CC=CS4)=NN3C5=CC=CC=C25)=O)C=C1

• Molecular Weight:

  437.31

• References & Citations:

  [1]Li X, et al., Small molecules capable of activating DNA methylation-repressed genes targeted by the p38 mitogen-activated protein kinase pathway. J Biol Chem. 2018 May 11;293(19):7423-7436.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  380645-50-1