LX-039
CAT:
804-HY-143439
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
LX-039
- CAS Number: 2135341-09-0
- UNSPSC Description: LX-039 is a highly potent, selective and orally active estrogen receptor degrader with EC50 value of 2.29 nM. LX-039 has indole C-3 chlorine atom. LX-039 exhibits excellent mouse pharmacokinetics, low clearance, high Cmax and oral exposure. LX-039 has anti-tumor activity[1].
- Target Antigen: Estrogen Receptor/ERR
- Type: Reference compound
- Related Pathways: Vitamin D Related/Nuclear Receptor
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/lx-039.html
- Solubility: 10 mM in DMSO
- Smiles: O=C(O)/C=C/C1=CC=C(/C(C(N2)=C(Cl)C3=C2C=CC=C3)=C(C4=CC=C(F)C=C4Cl)\CC)C=C1
- Molecular Weight: 480.36
- References & Citations: [1]Lu J, Chan CC, Sun D, et al. Discovery and preclinical profile of LX-039, a novel indole-based oral selective estrogen receptor degrader (SERD). Bioorg Med Chem Lett. 2022;66:128734.
- Shipping Conditions: Room temperature
- Clinical Information: Phase 1