Products for Research Use Only
RegisterLogin

PF-915275

CAT: 0804-HY-18056-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-18056-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
PF-915275 is a potent, selective and orally active human 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) inhibitor with a Ki of 2.3 nM and an EC50 of 15 nM (in HEK293 cells) . The dose-dependent effect of PF-915275 on conversion of cortisone to cortisol in primary human and monkey hepatocytes, with an EC50 of 20 and 100 nM, respectively[1][2][3].
CAS Number
857290-04-1
UNSPSC
12352005
Hazard Statement
H302
Target
11β-HSD
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/PF-915275.html
Concentration
10mM
Purity
99.74
Solubility
DMSO : ≥ 31 mg/mL
Smiles
N#CC1=CC=C(C2=CC=C(S(NC3=NC(N)=CC=C3)(=O)=O)C=C2)C=C1
Molecular Formula
C18H14N4O2S
Molecular Weight
350.39
Precautions
P264-P270-P330-P501
References & Citations
[1]Bhat BG, et al. Demonstration of proof of mechanism and pharmacokinetics and pharmacodynamic relationship with 4'-cyano-biphenyl-4-sulfonic acid (6-amino-pyridin-2-yl) -amide (PF-915275), an inhibitor of 11 -hydroxysteroid dehydrogenase type 1, in cynomolgus monkeys. J Pharmacol Exp Ther. 2008 Jan;324 (1) :299-305.|[2]Siu M, et al. N- (Pyridin-2-yl) arylsulfonamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1: Discovery of PF-915275. Bioorg Med Chem Lett. 2009 Jul 1;19 (13) :3493-7.|[3]Courtney R, et al. Modulation of 11beta-hydroxysteroid dehydrogenase (11betaHSD) activity biomarkers and pharmacokinetics of PF-00915275, a selective 11betaHSD1 inhibitor. J Clin Endocrinol Metab. 2008 Feb;93 (2) :550-6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1

Related Products

CatalogName
HY-P990649-01PF-5212374
HY-111965-01PF-06647263
HY-10459-01PF-562271
HY-108341-01PF-06424439
HY-100398-01PF-04979064
HY-131972-01PF-06843195
HY-14464-01PF-00489791
HY-121163-01PF-184563
HY-124947PF-4522654
HY-116524PF-04781340

Alternative Products

CatalogName
T16510-01PF-915275
3291/10PF 915275
A21330-5PF-915275 5mg
A21330-2PF-915275 2mg
A21330-500PF-915275 500mg
A21330-25PF-915275 25mg
A21330-100PF-915275 100mg
A21330-50PF-915275 50mg
A21330-10PF-915275 10mg
A21330-1PF-915275 1mg

Popular Products