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PF-915275

CAT: 0931-T16510-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T16510-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
857290-04-1
Target
Dehydrogenase, Others
Related Pathways
Metabolism, Others
Purity
0.9961
Bioactivity
PF-915275 is an effective and selective inhibitor of human 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1, Ki = 2.3 nM, EC50 = 15 nM in vitro HEK293 cells) . The dose-dependent effect of PF-915275 on conversion of cortisone to cortisol in primary human and monkey hepatocytes, with an EC50 of 20 and 100 nM, respectively.
Smiles
Nc1cccc(NS(=O)(=O)c2ccc(cc2)-c2ccc(cc2)C#N)n1
Molecular Formula
C18H14N4O2S
Molecular Weight
350.39
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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