PF-915275

• Target:

  Dehydrogenase|||Others

• Related Pathways:

  Metabolism|||Others

• Purity:

  0.9961

• Bioactivity:

  PF-915275 is an effective and selective inhibitor of human 11?-hydroxysteroid dehydrogenase type 1 (11?HSD1, Ki = 2.3 nM, EC50 = 15 nM in vitro HEK293 cells) . The dose-dependent effect of PF-915275 on conversion of cortisone to cortisol in primary human and monkey hepatocytes, with an EC50 of 20 and 100 nM, respectively.

• Smiles:

  Nc1cccc(NS(=O)(=O)c2ccc(cc2)-c2ccc(cc2)C#N)n1

• Molecular Formula:

  C18H14N4O2S

• Molecular Weight:

  350.39

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  857290-04-1