Alpha-Naphthoflavone

CAT: 0804-HY-125833-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-125833-01Size:5 mg
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Description
Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatasearomatase. IC 50 and K I value were 0.5 and 0.2 microns. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis[1][2][3][4].
CAS Number
[604-59-1]
UNSPSC
12352005
Hazard Statement
H302, H413
Target
Apoptosis; Aryl Hydrocarbon Receptor; Cytochrome P450
Type
Natural Products
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/alpha-naphthoflavone.html
Purity
99.76
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C1C=C(C2=CC=CC=C2)OC3=C1C=CC4=CC=CC=C43
Molecular Formula
C19H12O2
Molecular Weight
272.30
Precautions
H302, H413
References & Citations
[1]Campbell DR, et al. Flavonoid inhibition of aromatase enzyme activity in human preadipocytes. J Steroid Biochem Mol Biol. 1993 Sep;46 (3) :381-8.|[2]Cheng YW, et al. Alpha-naphthoflavone induces vasorelaxation through the induction of extracellular calcium influx and NO formation in endothelium. Naunyn Schmiedebergs Arch Pharmacol. 2003 Nov;368 (5) :377-85.|[3]Flores-Pérez A, et al. Apoptosis induction and inhibition of HeLa cell proliferation by alpha-naphthoflavone and resveratrol are aryl hydrocarbon receptor-independent. Chem Biol Interact. 2018 Feb 1;281:98-105.|[4]Xia H, et al. Alpha-naphthoflavone attenuates non-alcoholic fatty liver disease in oleic acid-treated HepG2 hepatocytes and in high fat diet-fed mice. Biomed Pharmacother. 2019 Oct;118:109287.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Aromatase/CYP19A1

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