Alpha-Naphthoflavone

• UNSPSC Description:

  Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatasearomatase. IC 50 and K I value were 0.5 and 0.2 microns. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis[1][2][3][4].

• Target Antigen:

  Apoptosis; Aryl Hydrocarbon Receptor; Cytochrome P450

• Type:

  Natural Products

• Related Pathways:

  Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/alpha-naphthoflavone.html

• Purity:

  98.54

• Solubility:

  DMSO : 25 mg/mL (ultrasonic)

• Smiles:

  O=C1C=C(C2=CC=CC=C2)OC3=C1C=CC4=CC=CC=C43

• Molecular Weight:

  272.30

• References & Citations:

  [1]Campbell DR, et al. Flavonoid inhibition of aromatase enzyme activity in human preadipocytes. J Steroid Biochem Mol Biol. 1993 Sep;46(3):381-8.|[2]Cheng YW, et al. Alpha-naphthoflavone induces vasorelaxation through the induction of extracellular calcium influx and NO formation in endothelium. Naunyn Schmiedebergs Arch Pharmacol. 2003 Nov;368(5):377-85.|[3]Flores-Pérez A, et al. Apoptosis induction and inhibition of HeLa cell proliferation by alpha-naphthoflavone and resveratrol are aryl hydrocarbon receptor-independent. Chem Biol Interact. 2018 Feb 1;281:98-105.|[4]Xia H, et al. Alpha-naphthoflavone attenuates non-alcoholic fatty liver disease in oleic acid-treated HepG2 hepatocytes and in high fat diet-fed mice. Biomed Pharmacother. 2019 Oct;118:109287.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Clinical Information:

  No Development Reported

• CAS Number:

  604-59-1