β-Naphthoflavone (Standard)

• Description:

  β-Naphthoflavone (Standard) is the analytical standard of β-Naphthoflavone. This product is intended for research and analytical applications. β-Naphthoflavone is an exogenous aryl hydrocarbon receptor (AHR) ligand. β-Naphthoflavone can activate AHR to participate in various biological processes, including cell growth, differentiation, apoptosis, and metabolism. β-Naphthoflavone has antioxidant activity and can exert its antioxidant function by regulating the activity of antioxidant enzymes. β-Naphthoflavone is also a non-carcinogenic CYP1A inducer and can be used to treat aristolochic acid (AAI) induced renal injury[1][2][3].

• UNSPSC:

  12352100

• Target:

  Apoptosis; Aryl Hydrocarbon Receptor; Reference Standards

• Related Pathways:

  Apoptosis; Immunology/Inflammation; Others

• Field of Research:

  Cancer; Neurological Disease

• Smiles:

  O=C1C2=C3C=CC=CC3=CC=C2OC(C4=CC=CC=C4)=C1

• Molecular Formula:

  C19H12O2

• Molecular Weight:

  272.30

• References & Citations:

  [1]Ishida T, Takechi S. β-Naphthoflavone, an exogenous ligand of aryl hydrocarbon receptor, disrupts zinc homeostasis in human hepatoma HepG2 cells. J Toxicol Sci. 2019;44 (10) :711-720.|[2]Zhu Y, et al. α- and β-Naphthoflavone synergistically attenuate H2O2-induced neuron SH-SY5Y cell damage. Exp Ther Med. 2017 Mar;13 (3) :1143-1150. |[3]Ying Xiao, et al. β-Naphthoflavone protects mice from aristolochic acid-I-induced acute kidney injury in a CYP1A dependent mechanism. Acta Pharmacologica Sinica 30.11 (2009) : 1559-1565.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  [6051-87-2]