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CCG-222740

CAT: 0804-HY-121750-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-121750-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CCG-222740 is an orally active and selective Rho/myocardin-related transcription factor (MRTF) pathway inhibitor[1]. CCG-222740 is also a potent inhibitor of alpha-smooth muscle actin protein expression. CCG-222740 effectively reduces fibrosis in skin and blocks melanoma metastasis[2].
CAS Number
1922098-69-8
UNSPSC
12352005
Hazard Statement
H302
Target
Ras; ROCK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; GPCR/G Protein; MAPK/ERK Pathway; Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ccg-222740.html
Purity
99.53
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(C1CN(C(C2=CC=CC(C3=CC=CO3)=C2)=O)CC(F)(F)C1)NC4=CC=C(Cl)C=C4
Molecular Formula
C23H19ClF2N2O3
Molecular Weight
444.86
Precautions
H302
References & Citations
[1]Leal AS, et al. The Rho/MRTF pathway inhibitor CCG-222740 reduces stellate cell activation and modulates immune cell populations in KrasG12D; Pdx1-Cre (KC) mice. Sci Rep. 2019 May 8;9 (1) :7072.|[2]Yu-Wai-Man C, et al. Local delivery of novel MRTF/SRF inhibitors prevents scar tissue formation in a preclinical model of fibrosis. Sci Rep. 2017 Mar 31;7 (1) :518.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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Alternative Products

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GTR19167416-01CCG-222740
A22348-10CCG-222740 10mg
A22348-100CCG-222740 100mg
A22348-25CCG-222740 25mg
A22348-2CCG-222740 2mg
A22348-200CCG-222740 200mg
A22348-50CCG-222740 50mg
A22348-5CCG-222740 5mg
A22348-10mM-DCCG-222740 10mM * 1mL in DMSO
M23376-01CCG-100602

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