Integrin alphaV beta3 (CD51/CD61, RGD-dependent Vitronectin Receptor) (FITC)

• Catalog number
  MBS606138
• Price
  Please ask
• Size
  5x0.1 mg

• Products_type
  Antibody
• Products_short_name
  [Integrin alphaV beta3]
• Products_name_syn
  [Anti -Integrin alphaV beta3 (CD51/CD61, RGD-dependent Vitronectin Receptor) (FITC)]
• Other_names
  [integrin beta-3; integrin beta-3; beta3 integrin; integrin beta 3; glycoprotein GPIIIa]
• Other_gene_names
  [ITGB3; CD61]
• Clonality
  Monoclonal
• Clone
  [9G192]
• Reactivity
  Human
• Specificity
  Recognizes human alpha-V/beta-3 integrin present on human endothelium cells.
• Purity
  Affinity Purified Purified.
• Form
  Supplied as a liquid in PBS, 1% BSA, 0.02% sodium azide. Labeled with fluorescein isothiocyanate (FITC).
• Storage_stability
  For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. FITC conjugates are sensitive to light.
• Tested_application
  Flow Cytometry (FC/FACS)
• Properties
  This MyBioSource Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS. When excited at 488 nanometers, FITC has a green emission that's usually collected at 530 nanometers, the FL1 detector of a FACSCalibur or FACScan. FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light. For fluorescent microscopy applications, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept. MyBioSource FITC is highly sensitive to pH extremes.
• Conjugation
  Anti-FITC Antibody
• Description
  The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.

• Gene target
  Integrin   alphaV   beta3   CD51/CD61   RGD-dependent   Vitronectin   Receptor  
• Gene symbol
  ITGB3, ITGAV
• Short name
  Integrin alphaV beta3 (CD51/CD61, RGD-dependent Vitronectin Receptor) (FITC)
• Technique
  FITC, Fluorescein
• Host
  Mouse
• Isotype
  IgG1
• Label
  FITC
• Alternative name
  Integrin alphaV beta3 (CD51/CD61, RGD-dependent Vitronectin Receptor) (fluorecein)
• Alternative technique
  fluorescine

Gene info

• Identity
  HGNC:6156
• Gene
  ITGB3
• Long gene name
  integrin subunit beta 3
• Synonyms gene
  • GP3A
• Synonyms gene name
  • integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
• Synonyms
  • CD61
  • GPIIIa
• Synonyms name
  • platelet glycoprotein IIIa
  • antigen CD61
• Locus
  17q21.32
• Discovery year
  1988-06-09
• Entrez gene record
  3690
• Pubmed identfication
  • 2454952
• RefSeq identity
  • NM_000212
• Classification
  • CD molecules
  • Integrin beta subunits
• VEGA ID
  OTTHUMG00000171956
• Locus Specific Databases
  • LRG_481

Gene info

• Identity
  HGNC:6150
• Gene
  ITGAV
• Long gene name
  integrin subunit alpha V
• Synonyms gene
  • VNRA
  • MSK8
  • VTNR
• Synonyms gene name
  • antigen identified by monoclonal antibody L230
  • vitronectin receptor
  • integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
  • integrin, alpha V
• Synonyms
  • CD51
• Locus
  2q32.1
• Discovery year
  1988-07-19
• Entrez gene record
  3685
• Pubmed identfication
  • 2454952
• RefSeq identity
  • NM_002210
• Classification
  • CD molecules
  • Integrin alpha subunits
• VEGA ID
  OTTHUMG00000132635

MeSH Data

• Name
  Fluorescent Antibody Technique
• Concept
  Scope note: Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
• Tree numbers
  • E01.370.225.500.607.512.240
  • E01.370.225.750.551.512.240
  • E05.200.500.607.512.240
  • E05.200.750.551.512.240
  • E05.478.583.375
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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