Integrin alphaV beta3 (CD51/CD61, RGD-dependent Vitronectin Receptor) (FITC)
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Catalog number
MBS606138
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Price
Please ask
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Size
0.1 mg
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Products_type
Antibody
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Products_short_name
[Integrin alphaV beta3]
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Products_name_syn
[Anti -Integrin alphaV beta3 (CD51/CD61, RGD-dependent Vitronectin Receptor) (FITC)]
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Other_names
[integrin beta-3; integrin beta-3; beta3 integrin; integrin beta 3; glycoprotein GPIIIa]
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Other_gene_names
[ITGB3; CD61]
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Clonality
Monoclonal
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Clone
[9G192]
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Reactivity
Human
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Specificity
Recognizes human alpha-V/beta-3 integrin present on human endothelium cells.
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Purity
Affinity Purified Purified.
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Form
Supplied as a liquid in PBS, 1% BSA, 0.02% sodium azide. Labeled with fluorescein isothiocyanate (FITC).
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Storage_stability
For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. FITC conjugates are sensitive to light.
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Tested_application
Flow Cytometry (FC/FACS)
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Properties
This MyBioSource Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS. When excited at 488 nanometers, FITC has a green emission that's usually collected at 530 nanometers, the FL1 detector of a FACSCalibur or FACScan. FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light. For fluorescent microscopy applications, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept. MyBioSource FITC is highly sensitive to pH extremes.
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Conjugation
Anti-FITC Antibody
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Description
The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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Gene target
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Gene symbol
ITGB3, ITGAV
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Short name
Integrin alphaV beta3 (CD51/CD61, RGD-dependent Vitronectin Receptor) (FITC)
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Technique
FITC, Fluorescein
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Host
Mouse
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Isotype
IgG1
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Label
FITC
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Alternative name
Integrin alphaV beta3 (CD51/CD61, RGD-dependent Vitronectin Receptor) (fluorecein)
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Alternative technique
fluorescine
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Gene info
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Identity
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Gene
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Long gene name
integrin subunit beta 3
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Synonyms gene
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Synonyms gene name
- integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
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Synonyms
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Synonyms name
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Locus
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Discovery year
1988-06-09
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- CD molecules
- Integrin beta subunits
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene name
integrin subunit alpha V
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Synonyms gene
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Synonyms gene name
- antigen identified by monoclonal antibody L230
- vitronectin receptor
- integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
- integrin, alpha V
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Synonyms
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Locus
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Discovery year
1988-07-19
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- CD molecules
- Integrin alpha subunits
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VEGA ID
MeSH Data
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Name
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Concept
Scope note:
A method for the study of certain organic compounds within cells, in situ, by measuring the light intensities of the selectively stained areas of cytoplasm. The compounds studied and their locations in the cells are made to fluoresce and are observed under a microscope.
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Tree numbers
- E01.370.225.500.386
- E05.196.712.516.600.240
- E05.200.500.386
- E05.242.386
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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