CD51/CD61 Integrin alphaV beta3 (RGD-dependent Vitronectin Receptor)
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Catalog numberGEN603512
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PricePlease ask
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Size100ug
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Also known asCD51/CD61 Integrin alphaV beta3
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Other namesN/A
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CategoryAntibodies
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SubcategoryMnoclonal antibodies
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Gene nameN/A
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Gene name synonimsN/A
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Other gene namesN/A
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ClonalityMonoclonal
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Immunoglobulin isotypeIgG1
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Clone4j22
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Host organismMouse (Mus musculus)
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Source organismHuman (Homo sapiens)
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Species reactivityChicken, Human (Homo sapiens); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
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Specificity and cross reactivityRecognizes the intact complex formed between the CD51 and CD61 molecules (alpha V and beta 3 integrins). This complex binds vitronectin at the RGD sequence and can also bind fibrinogen, von Willebrand factor, thrombospondin, fibronectin, osteopontin and collagen. Reacts with osteoclasts, placenta, melanoma cell lines and weakly with platelets. Species Crossreactivity: Human and chicken. Does not crossreact with porcine, lapine or bovine tissue.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
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Purification methodAffinity Purified by affinity chromatography on Protein A from tissue culture supernatant
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Form AppearanceSupplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
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ConcentrationN/A
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Storage and shippingStore the antibody at +4 degrees Celsius for short term storage.. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze the antibody should be stored at -20 degrees Celsius.. Aliquots are stable for at least 12 months the antibody should be stored at -20 degrees Celsius.. Prior to use, briefly centrifuge the original vial after thawing and before lid. If further dilution(s) are needed, they can be done with the appropriate assay buffer.
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Tested applicationsImmunoprecipitation (IP), Flow Cytometry (FC/FACS)
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DescriptionThe receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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Gene target
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Gene symbolITGB3, ITGAV
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Short nameCD51/CD61 Integrin alphaV beta3 (RGD-dependent Vitronectin Receptor)
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Alternative nameAnti-CD51/CD61 Integrin alphaV beta3 (RGD-dependent Vitronectin Receptor)
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Gene info
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Identity
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Gene
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Long gene nameintegrin subunit beta 3
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Synonyms gene
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Synonyms gene name
- integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
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Synonyms
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Synonyms name
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Locus
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Discovery year1988-06-09
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- CD molecules
- Integrin beta subunits
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameintegrin subunit alpha V
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Synonyms gene
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Synonyms gene name
- antigen identified by monoclonal antibody L230
- vitronectin receptor
- integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
- integrin, alpha V
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Synonyms
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Locus
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Discovery year1988-07-19
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- CD molecules
- Integrin alpha subunits
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VEGA ID