IL3RB (CD131, Cytokine Receptor Common Subunit beta, CDw131, GM-CSF/IL-3/IL-5 Receptor Common beta Subunit, CSF2RB, IL5RB)

• Catalog number
  MBS647780
• Price
  Please ask
• Size
  0.05 mg

• Products_type
  Antibody
• Products_short_name
  [IL3RB]
• Products_name_syn
  [Anti -IL3RB (CD131, Cytokine Receptor Common Subunit beta, CDw131, GM-CSF/IL-3/IL-5 Receptor Common beta Subunit, CSF2RB, IL5RB)]
• Other_names
  [interleukin-3 receptor class 2 subunit beta; Interleukin-3 receptor class 2 subunit beta; interleukin-3 receptor class 2 subunit beta; IL-3R class 2 subunit beta; IL-3 receptor class 2 subunit beta; interleukin-3 receptor class II beta chain; colony-stimulating factor 2 receptor subunit beta-2; colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage); Colony-stimulating factor 2 receptor subunit beta-2; Interleukin-3 receptor class II beta chain]
• Other_gene_names
  [Csf2rb2; Csf2rb2; Bil3; Il3r; AIC2A; Il3rb; Il3rb2; BetaIl3; Csfgmrb; Ai2ca; Il3r; Il3rb2; IL-3 receptor class 2 subunit beta]
• Clonality
  Polyclonal
• Reactivity
  Mouse, Rat
• Specificity
  Recognizes human CSF2RB/CD131. Species Crossreactivity: Mouse, rat.
• Purity
  Affinity Purified Purified by immunoaffinity chromatography.
• Form
  Supplied as a liquid in PBS, (without Mg2+, Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
• Storage_stability
  May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Tested_application
  ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Description
  Cytokines and Chemokines are chemotaxis related small proteins between 5 to 20 kDa. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
• Gene
  Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages, T cells, mast cells, NK cells, endothelial cells and fibroblasts that functions as a cytokine. The pharmaceutical analogs of naturally occurring GM-CSF are called sargramostim and molgramostim. Reconstitution It is recommended that sterile ddH2O containing at least 0.1% human serum albumin or bovine serum albumin be added to the vial to prepare a stock solution of not less than 1 mg/mL of the cytokine.

• Gene target
  IL3RB   CD131   Cytokine   Receptor   Common   Subunit   beta   CDw131   GM-CSF/IL-3/IL-5   Receptor   Common   beta   Subunit   CSF2RB   IL5RB  
• Gene symbol
  CSF2RB, IL3, CSF2, IL5, IL36G, IL25, IL22, IL18, IL37, IL6R
• Short name
  IL3RB (CD131, Cytokine Receptor Common Subunit beta, CDw131, GM-CSF/IL-3/IL-5 Receptor Common beta Subunit, CSF2RB, IL5RB)
• Host
  Rabbit
• Isotype
  IgG
• Alternative name
  IL3RB (CD131, Cytokine Receptor Common functionnal sequence b, CDw131, GM-CSF/Interleukin-3/Interleukin-5 Receptor Common b functionnal sequence, colony stimulating factor 2 receptor, b, low-affinity (granulocyte-macrophage), IL5RB)
• Alternative to gene target
  colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage), CD131 and CDw131 and IL3RB and IL5RB and SMDP5, CSF2RB and IDBG-6178 and ENSG00000100368 and 1439, protein binding, Plasma membranes, CSF2RB and IDBG-638112 and ENSBTAG00000009064 and 528530

Gene info

• Identity
  HGNC:2436
• Gene
  CSF2RB
• Long gene name
  colony stimulating factor 2 receptor subunit beta
• Synonyms gene
  • IL3RB
• Synonyms gene name
  • colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
  • colony stimulating factor 2 receptor beta common subunit
• Synonyms
  • IL5RB
  • CD131
  • betaGMR
• Synonyms name
  • beta common cytokine receptor
  • beta-GM-CSF receptor
• GenBank acession
  • M59941
• Locus
  22q12.3
• Discovery year
  1991-08-07
• Entrez gene record
  1439
• Pubmed identfication
  • 1833064
  • 1424804
• RefSeq identity
  • NM_000395
• Classification
  • Fibronectin type III domain containing
  • CD molecules
• VEGA ID
  OTTHUMG00000150546

Gene info

• Identity
  HGNC:6011
• Gene
  IL3
• Long gene name
  interleukin 3
• Synonyms gene name
  • interleukin 3 (colony-stimulating factor, multiple)
• Synonyms
  • IL-3
  • MULTI-CSF
  • MCGF
  • MGC79398
  • MGC79399
• Synonyms name
  • multilineage-colony-stimulating factor
  • hematopoietic growth factor
  • P-cell stimulating factor
  • mast-cell growth factor
  • colony-stimulating factor, multiple
• GenBank acession
  • M14743
• Locus
  5q31.1
• Discovery year
  2001-06-22
• Entrez gene record
  3562
• Pubmed identfication
  • 3489530
• RefSeq identity
  • NM_000588
• Classification
  • Interleukins
• VEGA ID
  OTTHUMG00000059640

Gene info

• Identity
  HGNC:2434
• Gene
  CSF2
• Long gene name
  colony stimulating factor 2
• Synonyms gene name
  • colony stimulating factor 2 (granulocyte-macrophage)
• Synonyms
  • GM-CSF
  • GMCSF
• Synonyms name
  • sargramostim
  • molgramostim
  • granulocyte-macrophage colony stimulating factor
• GenBank acession
  • M11734
• Locus
  5q31.1
• Discovery year
  2001-06-22
• Entrez gene record
  1437
• Pubmed identfication
  • 3898082
  • 2999978
• RefSeq identity
  • NM_000758
• VEGA ID
  OTTHUMG00000059637

Gene info

• Identity
  HGNC:6016
• Gene
  IL5
• Long gene name
  interleukin 5
• Synonyms gene name
  • interleukin 5 (colony-stimulating factor, eosinophil)
• Synonyms
  • IL-5
  • EDF
  • TRF
• Synonyms name
  • interleukin-5
  • T-cell replacing factor
  • B cell differentiation factor I
  • eosinophil differentiation factor
  • colony-stimulating factor, eosinophil
• GenBank acession
  • X04688
• Locus
  5q31.1
• Discovery year
  2001-06-22
• Entrez gene record
  3567
• Pubmed identfication
  • 3498940
• RefSeq identity
  • NM_000879
• Classification
  • Interleukins
• VEGA ID
  OTTHUMG00000059496

Gene info

• Identity
  HGNC:15741
• Gene
  IL36G
• Long gene name
  interleukin 36 gamma
• Synonyms gene
  • IL1F9
• Synonyms gene name
  • interleukin 1 family, member 9
• Synonyms
  • IL-1H1
  • IL-1RP2
  • IL-1F9
  • IL1H1
  • IL1E
• Synonyms name
  • interleukin-1 homolog 1
  • interleukin 1-related protein 2
  • interleukin-1 epsilon
• GenBank acession
  • AF200492
• Locus
  2q14.1
• Discovery year
  2002-08-02
• Entrez gene record
  56300
• Pubmed identfication
  • 10860666
  • 10744718
  • 11991722
  • 11991723
• RefSeq identity
  • NM_019618
• Classification
  • Interleukins
• VEGA ID
  OTTHUMG00000131336

Gene info

• Identity
  HGNC:13765
• Gene
  IL25
• Long gene name
  interleukin 25
• Synonyms gene
  • IL17E
• Synonyms gene name
  • interleukin 17E
• Synonyms
  • IL-25
  • IL-17E
• GenBank acession
  • AF305200
• Locus
  14q11.2
• Discovery year
  2001-01-26
• Pubmed identfication
  • 11058597
  • 11754819
• Classification
  • Interleukins
• VEGA ID
  OTTHUMG00000028749

Gene info

• Identity
  HGNC:14900
• Gene
  IL22
• Long gene name
  interleukin 22
• Synonyms
  • ILTIF
  • IL-21
  • zcyto18
  • IL-TIF
  • IL-D110
  • TIFa
  • TIFIL-23
  • IL-22
  • MGC79382
  • MGC79384
• Synonyms name
  • IL-10-related T-cell-derived inducible factor
• GenBank acession
  • AF279437
• Locus
  12q15
• Discovery year
  2001-03-12
• Entrez gene record
  50616
• Pubmed identfication
  • 10954742
  • 10875937
• RefSeq identity
  • NM_020525
• Classification
  • Interleukins
• VEGA ID
  OTTHUMG00000169119
• Locus Specific Databases
  • LRG_1248

Gene info

• Identity
  HGNC:5986
• Gene
  IL18
• Long gene name
  interleukin 18
• Synonyms gene name
  • interleukin 18 (interferon-gamma-inducing factor)
• Synonyms
  • IGIF
  • IL1F4
  • IL-1g
  • IL-18
• Synonyms name
  • interferon-gamma-inducing factor
• GenBank acession
  • U90434
• Locus
  11q23.1
• Discovery year
  1997-07-25
• Entrez gene record
  3606
• Pubmed identfication
  • 7477296
  • 9693051
• RefSeq identity
  • NM_001562
• Classification
  • Interleukins
• VEGA ID
  OTTHUMG00000167006

Gene info

• Identity
  HGNC:15563
• Gene
  IL37
• Long gene name
  interleukin 37
• Synonyms gene
  • IL1F7
• Synonyms gene name
  • interleukin 1 family, member 7 (zeta)
• Synonyms
  • FIL1
  • FIL1Z
  • FIL1(ZETA)
  • IL-1H4
  • IL-1RP1
  • IL-1F7
• Synonyms name
  • interleukin 1, zeta
  • interleukin-1 homolog 4
  • interleukin-1-related protein
• GenBank acession
  • AF201832
• Locus
  2q14.1
• Discovery year
  2002-08-02
• Entrez gene record
  27178
• Pubmed identfication
  • 10625660
  • 10512743
  • 12496389
• RefSeq identity
  • NM_014439
• Classification
  • Interleukins
• VEGA ID
  OTTHUMG00000131345

Gene info

• Identity
  HGNC:6019
• Gene
  IL6R
• Long gene name
  interleukin 6 receptor
• Synonyms
  • CD126
  • IL-6R
  • IL-1Ra
  • IL6RA
  • gp80
• Synonyms name
  • membrane glycoprotein 80
  • interleukin 6 receptor subunit alpha
• GenBank acession
  • X12830
• Locus
  1q21.3
• Discovery year
  2001-06-22
• Entrez gene record
  3570
• Pubmed identfication
  • 8428753
  • 12633863
• RefSeq identity
  • NM_000565
• Classification
  • CD molecules
  • Interleukin receptors
  • Immunoglobulin like domain containing
• VEGA ID
  OTTHUMG00000036073

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