BACE, Asp2 (CT) (Beta-site APP Cleaving Enzyme, Aspartyl Protease 2)

Products_type

Antibody
Products_short_name

[BACE, Asp2]
Products_name_syn

[Anti -BACE, Asp2 (CT) (Beta-site APP Cleaving Enzyme, Aspartyl Protease 2)]
Other_names

[beta-secretase 1 isoform D preproprotein; Beta-secretase 1; beta-secretase 1; asp 2; memapsin-2; APP beta-secretase; aspartyl protease 2; beta-site APP cleaving enzyme 1; beta-secretase 1 precursor variant 1; transmembrane aspartic proteinase Asp2; membrane-associated aspartic protease 2; beta-site amyloid beta A4 precursor protein-cleaving enzyme; beta-site APP-cleaving enzyme 1; Aspartyl protease 2; ASP2; Asp 2; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; Memapsin-2; Membrane-associated aspartic protease 2]
Other_gene_names

[BACE1; BACE1; ASP2; BACE; HSPC104; BACE; KIAA1149; ASP2; Asp 2]
Clonality

Polyclonal
Reactivity

Human, Mouse
Specificity

Recognizes human and mouse BACE/Asp2 (CT)
Purity

Highly Purified Supplied as chromatographically purified IgG
Form

Supplied as a liquid in PBS, 0.02% sodium azide.
Storage_stability

-20 degree C
Tested_application

Western Blot (WB)
Description

Enzymes are cleaving the substrate. If the substrate is DNA they are called restriction enzymes. Activating enzymes will cut off the domain that is biological active to become functional.

Gene target

BACE Asp2 Beta-site APP Cleaving Aspartyl Protease
Gene symbol

APP-DT, BACE1, APP, PABPC4, NAE1
Short name

BACE, Asp2 (CT) (Beta-site APP Cleaving Enzyme, Aspartyl Protease 2)
Technique

Enzyme, enzymes
Host

Rabbit
Isotype

IgG
Alternative name

BACE, Asp2 (CT) (b-site amyloid beta (A4) precursor protein Cleaving Enzyme, Aspartyl Protease 2)
Alternative technique

enzymes
Alternative to gene target

amyloid beta (A4) precursor protein, AAA and ABETA and ABPP and AD1 and APPI and CTFgamma and CVAP and PN-II and PN2, APP and IDBG-1100 and ENSG00000142192 and 351, growth factor receptor binding, nuclei, App and IDBG-172954 and ENSMUSG00000022892 and 11820, APP and IDBG-630293 and ENSBTAG00000017753 and 280722

Identity

HGNC:933
Gene

BACE1
Long gene name

beta-secretase 1
Synonyms gene
- BACE
Synonyms gene name
- beta-site APP-cleaving enzyme
- beta-site APP-cleaving enzyme 1
GenBank acession
- AF190725
Locus

11q23.3
Discovery year

1999-10-29
Entrez gene record

23621
Pubmed identfication
- 10531052
Classification
- Peptidase family A1
VEGA ID

OTTHUMG00000160636

Identity

HGNC:620
Gene

APP
Long gene name

amyloid beta precursor protein
Synonyms gene
- AD1
Synonyms gene name
- Alzheimer disease
- amyloid beta (A4) precursor protein
Synonyms
- alpha-sAPP
Synonyms name
- peptidase nexin-II
GenBank acession
- M15533
Locus

21q21.3
Discovery year

1986-01-01
Entrez gene record

351
Pubmed identfication
- 1679289
RefSeq identity
- NM_000484
Classification
- Receptor ligands
VEGA ID

OTTHUMG00000078438
Locus Specific Databases
- Alzheimer Disease & Frontotemporal Dementia Mutation Database

Identity

HGNC:8557
Gene

PABPC4
Long gene name

poly(A) binding protein cytoplasmic 4
Synonyms gene name
- poly(A)-binding protein, cytoplasmic 4 (inducible form)
- poly(A) binding protein, cytoplasmic 4 (inducible form)
Synonyms
- iPABP
- APP-1
Synonyms name
- activated-platelet protein 1
- Inducible poly(A)-binding protein
GenBank acession
- U33818
Locus

1p34.3
Discovery year

1999-12-17
Entrez gene record

8761
Pubmed identfication
- 10543404
RefSeq identity
- NM_001135653
Classification
- RNA binding motif containing
- Small nucleolar RNA protein coding host genes
VEGA ID

OTTHUMG00000009097