BACE, Asp2 Beta-Secretase Peptide Substrate, Human (Memapsin2, Beta-site APP Cleaving Enzyme, Aspartyl Protease 2)

• Catalog number
  MBS659240
• Price
  Please ask
• Size
  5x0.1 mg

• Products_type
  Peptide
• Products_short_name
  [BACE, Asp2 Beta-Secretase Peptide Substrate]
• Other_names
  [Beta-secretase 1; Beta-secretase 1; beta-secretase 1; asp 2; memapsin-2; APP beta-secretase; aspartyl protease 2; beta-site APP cleaving enzyme 1; beta-secretase 1 precursor variant 1; transmembrane aspartic proteinase Asp2; membrane-associated aspartic protease 2; beta-site amyloid beta A4 precursor protein-cleaving enzyme; beta-site APP-cleaving enzyme 1; Aspartyl protease 2; ASP2; Asp 2; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; Memapsin-2; Membrane-associated aspartic protease 2]
• Other_gene_names
  [BACE1; BACE1; ASP2; BACE; HSPC104; BACE; KIAA1149; ASP2; Asp 2]
• Purity
  Highly PurifiedHighly purified
• Form
  Supplied as liquid.
• Storage_stability
  -20 degree C
• Tested_application
  ELISA (EL/EIA), Western Blot (WB)
• Description
  Enzymes are cleaving the substrate. If the substrate is DNA they are called restriction enzymes. Activating enzymes will cut off the domain that is biological active to become functional. Peptides short amino acid chains or epitopes or blocking antagonists. The shortest peptides are dipeptides, consisting of 2 amino acids joined by a single peptide bond, followed by tripeptides, tetra peptides, ... till polypeptides that are long, continuous, and unbranched synthetic peptide chains. These biological oligomers and polymers can be Solid-phase peptide synthesis (SPPS), or in continue produced for custom peptide synthesis projects. The High-efficiency solid phase peptide synthesis (HE-SPPS) is give very low production costs.
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

• Gene target
  BACE   Asp2   Beta-Secretase   Peptide   Substrate   Memapsin2   Beta-site   APP   Cleaving   Aspartyl   Protease  
• Gene symbol
  APP-DT, BACE1, APP, PABPC4, NAE1
• Short name
  BACE, Asp2 Beta-Secretase Peptide Substrate, (Memapsin2, Beta-site APP Cleaving Enzyme, Aspartyl Protease 2)
• Technique
  peptide, Enzyme, enzymes, peptides
• Host
  Human
• Species
  Human, Humans
• Alternative name
  BACE, Asp2 b-Secretase short protein sequence Substrate, H. sapiens (Memapsin2, b-site amyloid beta (A4) precursor protein Cleaving Enzyme, Aspartyl Protease 2)
• Alternative technique
  peptides, enzymes
• Alternative to gene target
  amyloid beta (A4) precursor protein, AAA and ABETA and ABPP and AD1 and APPI and CTFgamma and CVAP and PN-II and PN2, APP and IDBG-1100 and ENSG00000142192 and 351, growth factor receptor binding, nuclei, App and IDBG-172954 and ENSMUSG00000022892 and 11820, APP and IDBG-630293 and ENSBTAG00000017753 and 280722

Gene info

• Identity
  HGNC:55075
• Gene
  APP-DT
• Long gene name
  APP divergent transcript
• Locus
  21q21.3
• Discovery year
  2020-06-12
• Classification
  • Divergent transcripts

Gene info

• Identity
  HGNC:933
• Gene
  BACE1
• Long gene name
  beta-secretase 1
• Synonyms gene
  • BACE
• Synonyms gene name
  • beta-site APP-cleaving enzyme
  • beta-site APP-cleaving enzyme 1
• GenBank acession
  • AF190725
• Locus
  11q23.3
• Discovery year
  1999-10-29
• Entrez gene record
  23621
• Pubmed identfication
  • 10531052
• Classification
  • Peptidase family A1
• VEGA ID
  OTTHUMG00000160636

Gene info

• Identity
  HGNC:620
• Gene
  APP
• Long gene name
  amyloid beta precursor protein
• Synonyms gene
  • AD1
• Synonyms gene name
  • Alzheimer disease
  • amyloid beta (A4) precursor protein
• Synonyms
  • alpha-sAPP
• Synonyms name
  • peptidase nexin-II
• GenBank acession
  • M15533
• Locus
  21q21.3
• Discovery year
  1986-01-01
• Entrez gene record
  351
• Pubmed identfication
  • 1679289
• RefSeq identity
  • NM_000484
• Classification
  • Receptor ligands
• VEGA ID
  OTTHUMG00000078438
• Locus Specific Databases
  • Alzheimer Disease & Frontotemporal Dementia Mutation Database

Gene info

• Identity
  HGNC:8557
• Gene
  PABPC4
• Long gene name
  poly(A) binding protein cytoplasmic 4
• Synonyms gene name
  • poly(A)-binding protein, cytoplasmic 4 (inducible form)
  • poly(A) binding protein, cytoplasmic 4 (inducible form)
• Synonyms
  • iPABP
  • APP-1
• Synonyms name
  • activated-platelet protein 1
  • Inducible poly(A)-binding protein
• GenBank acession
  • U33818
• Locus
  1p34.3
• Discovery year
  1999-12-17
• Entrez gene record
  8761
• Pubmed identfication
  • 10543404
• RefSeq identity
  • NM_001135653
• Classification
  • RNA binding motif containing
  • Small nucleolar RNA protein coding host genes
• VEGA ID
  OTTHUMG00000009097

Gene info

• Identity
  HGNC:621
• Gene
  NAE1
• Long gene name
  NEDD8 activating enzyme E1 subunit 1
• Synonyms gene
  • APPBP1
• Synonyms gene name
  • amyloid beta precursor protein binding protein 1, 59kDa
• Synonyms
  • ula-1
  • APP-BP1
• GenBank acession
  • U50939
• Locus
  16q22.1
• Discovery year
  1999-01-13
• Entrez gene record
  8883
• Pubmed identfication
  • 8626687
  • 12740388
• RefSeq identity
  • NM_003905
• Classification
  • Ubiquitin like modifier activating enzymes
• VEGA ID
  OTTHUMG00000137513

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